• Medical_Professionals
• Medical_students
• Nurses

The remarkable stability of the human genome is lost in cancer cells due to the failure of efficient and accurate repair in the context of oncogene-induced replication stress and elevated transcription. DNA replication is furthermore emerging as a surprisingly fragile and complex process requiring fork protection and restart, template-switching, R-loop resolution, gap-filling, and repair. Unresolved replication and repair intermediates signal apoptosis. The synthetic lethality and essentiality resulting from replication-repair stresses thus suggest repair inhibitors as tools to control pathway selection and damage outcomes and to design advanced therapeutics.

The 3rd DNA Replication/Repair Structures & Cancer conference in February 2018 will focus on structural and mechanistic insights into dynamic protein, chromatin, DNA and RNA complexes acting in DNA replication and repair events relevant to cancer. Conference talks and discussions will center on developing an actionable mechanistic knowledge of DNA replication and repair stress responses suitable to guide advanced intervention strategies for cancer. The conference will emphasize an environment suitable for initiating productive collaborations. It will include vibrant informal and formal discussions together with informative talks and poster sessions.

To include late-breaking advances and innovating new investigators, one or more talks for every session will be selected from submitted abstracts. Meeting attendance is limited. Applicants seeking to present talks or posters are strongly encouraged to submit applications and abstracts early. All presenters are asked to focus on unpublished work, cutting-edge approaches and novel mechanistic insights that aid prediction of biological outcomes and plans to best apply basic research advances for cancer research and treatment.

What makes this meeting unique? Professor Ben Van Houten from the University of Pittsburgh says:

‘I can honestly say your meeting, by combining hard core structure-function studies with beautiful biology, hits an important area that many meetings miss; being part of that science is just terrific.’

Join the conference LinkedIn group to keep up to date with announcements and latest news concerning the conference.

Key Sessions

Sessions will include emerging results and breakthrough methods concerning:

Repair and replication complexes, structures and mechanisms

Mutational signatures, kataegis, DNA repair, and cancer

Damage signaling, pathway selection & cross-talk

Targeting synthetic lethality and essentiality for damage responses

Chromatin and chromosome instability

Epigenetics, DNA damage and repair

PARP, PARG, and metabolic signaling

Mitochondrial replication/repair and damage signaling

RNA damage responses and actions in repair

DNA repair, apoptosis and cancer

Student Offer

Take advantage of this fantastic opportunity for students! Register an academic at the standard rate of $1,854 and bring a student for only $850. Unfortunately, Postdocs are not eligible. Both registration packages include; accommodation for the 11th, 12th, 13th and 14th February 2018 (on a shared basis for students, note guest rooms are open plan) and a 24hour all-inclusive food and beverage package for the conference period. Once you have registered and paid in full, please contact Laura Trundle (laura@fusion-conferences.com) to obtain a special registration link for your student.

Steve Jackson (University of Cambridge)

'CELLULAR RESPONSES TO DNA DOUBLE-STRAND BREAKS'

Bruce Stillman (CSHL)

'THE ORIGIN RECOGNITION COMPLEX AND CHROMOSOME DUPLICATION: STRUCTURE, FUNCTION AND HUMAN GENETICS'

Steve West (The Francis Crick Institute)

'UNRESOLVED DNA INTERMEDIATES AS A SOURCE OF DNA BREAKS AND CHROMOSOME ABERRATIONS'

Serena Nik-Zainal (Wellcome Trust Sanger Institute)

'ADVANCES IN THE FIELD OF MUTATIONAL SIGNATURES: MECHANISTIC INSIGHTS AND CLINICAL APPLICATIONS'

Our registration fees are inclusive of the following during the conference period only:

- Conference registration.

- 4 nights’ fixed accommodation (11, 12, 13 and 14 February 2018) on a single basis for academics and industry, on a shared basis for students.

- Breakfast, Lunch and Dinner – available at all restaurants according to operational hours or programmed events.

- International Bar available by the glass in restaurants and bars according to operational hours.

- Pool snacks and International Bar available by the glass at pool area.

- Minibar including: soft drinks, domestic beer, bottled water and coffee. Refreshed daily.

- 24 Hour Room Service.

- In room amenity – bottle of wine, per room, per stay.

- Gala Night entry (includes an open bar).

- Complimentary WIFI in both conference rooms and your guest room.

What\'s Included in our Accompanying Adult Fees?

Our accompanying adult fees are inclusive of the following during the conference period only:

- 4 nights’ fixed accommodation (11, 12, 13 and 14 February 2018) on a shared basis with a conference participant.

- Breakfast, Lunch and Dinner – available at all restaurants according to operational hours or programmed events.

- International Bar available by the glass in restaurants and bars according to operational hours.

- Pool snacks and International Bar available by the glass at pool area.

- Minibar including: soft drinks, domestic beer, bottled water and coffee. Refreshed daily.

- 24 Hour Room Service.

- In room amenity – bottle of wine, per room, per stay.

- Gala Night entry (includes an open bar).

- Complimentary WIFI in both conference rooms and your guest room.

Important Note: Accompanying persons are not permitted access to the conference.

What\'s Included in our Accompanying Child Fees?

Our accompanying child fees are inclusive of the following during the conference period only:

- 4 nights’ fixed accommodation (11, 12, 13 and 14 February 2018) on a shared basis with the parent/s.

- Breakfast, Lunch and Dinner – available at all restaurants according to operational hours or programmed events.

- International Bar available by the glass in restaurants and bars according to operational hours.

- Pool snacks and International Bar available by the glass at pool area.

- Minibar including: soft drinks, bottled water and coffee. Refreshed daily.

- 24 hour room service.

- Gala Night entry (includes soft drinks).

- Complimentary WIFI in both conference rooms and your guest room. 

Important Note: Accompanying child fees are applicable for children aged 5-12 years. Children aged 0-4 years stay free of charge with a parent. Children aged 13 years and older are classified as an adult at this venue (Fiesta Americana Condesa). Roll out beds are available upon request but can only be guaranteed at the point of check-in

USD

Group registrations not allowed

Accompanying persons not allowed

We don’t accept Online Abstracts

Fiesta Americana Condesa

Cancun, Mexico

Fiesta Americana CondesaFiesta Americana CondesaFiesta Americana CondesaFiesta Americana CondesaFiesta Americana CondesaVenue Rating5 StarsCurrencyUS Dollar (USD)AddressFiesta Americana Condesa,

Blvd.Kukulkán km 16.5 Zona Hotelera,

Cancun,

77500

MexicoNearest AirportCancun International Airport

Hotel Details

This stylish hotel features contemporary Mexican architecture, including one of the largest and most impressive thatched-roof "palapas" in the entire country. There are cultural activities, arts and crafts and sports programs to keep you constantly entertained, plus time to relax and enjoy the Mayan culture, soak up the Caribbean sunshine and revel in the international ambiance that settles in after the sun goes down.

Throughout your stay delegates will enjoy a full meal plan, inclusive of beverages. Take your pick from the aromatic Asian delights at Kaumbu, traditional fare at El Mexicano, delicious international cuisine at Kalmia Buffet or perhaps sample the sumptuous Italian dishes at Rosato. There are also several other dining opportunities such as the Cevichería, Pizzeria, Sushi Corner, pool and lounge bar areas. The Gala Night with either a Mayan or Caribbean theme takes place on the third evening of the conference with a mouth-watering feast of local cuisine, an open bar and amazing local entertainment.  We welcome all delegates and their accompanying persons to the Gala Night – a truly fun filled night not to be missed!

Submission Info

Office address

Unit 5D, Lynx Business Park

Fordham Road

Snailwell

Newmarket

CB8 7NY

United Kingdom

Office numbers

Tel: +44 (0) 1638 724137

Fax: +44 (0) 1638 724135

Office contact

Skype: Fusion.Conferences

Email: admin@fusion-conferences.com

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Bronze

Media Partners

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Office address

Unit 5D, Lynx Business Park

Fordham Road

Snailwell

Newmarket

CB8 7NY

United Kingdom

Office numbers

Tel: +44 (0) 1638 724137

Fax: +44 (0) 1638 724135

Office contact

Skype: Fusion.Conferences

Email: admin@fusion-conferences.com