• Medical_Professionals
• Medical_students
• Nurses

Once thought of merely as byproducts of cellular metabolism, we now appreciate how metabolites can directly impact a myriad of processes, from signalling to gene expression, in cells. Cells adapt metabolism to allow ATP production and the redistribution of carbons to nucleotide, protein, and fatty acid syntheses to support their physiological functions. Metabolism can also influence cell state, with increasing evidence that changes in metabolite levels can affect both pathway regulation and gene expression, particularly through the effects of these metabolites on chromatin modifications. One example driven by genetic mutations is the role played by “oncometabolites,” which can impact the activity of enzymes that control epigenetic state. Such crosstalk between metabolism and epigenetics appears to be bi-directional, with multiple epigenetic enzymes acting as rheostats to readjust metabolism following nutrient changes. More recent studies determined that alterations in the microbiome influence availability of metabolites, in turn affecting signaling, cell proliferation, and chromatin. Lastly, changes in metabolites with age can impact both Sirtuins and PARP enzymes, influencing diverse pathways, including epigenetics and DNA repair.

This meeting will bring together scientists studying metabolites and their signaling properties and how they affect many aspects of health, including aging and cancer.

Topics:

Metabolite Regulation of Epigenetics and Gene Expression

Metabolites and Signaling

Metabolites in Cancer

Metabolites in Organismal Physiology and Aging

Metabolites and the Microbiota

Donita Brady, USA

Andrew Dillin, USA

Sarah-Maria Fendt, Belgium

Eyal Gottlieb, Israel

Marcia Haigis, USA

Barbara Kahn, USA

Lee Kraus, USA

Mitch Lazar, USA

Jason Locasale, USA

Raul Mostoslavsky, USA

Luke O’Neill, Ireland

Federico Rey, USA

Benjamin Tu, USA

Amy Walker, USA

Kathryn Wellen, USA

Yingming Zhao, USA

USD

Group registrations not allowed

Accompanying persons not allowed

We don’t accept Online Abstracts

Motif Seattle,

1415 Fifth Avenue,

Seattle, Washington, United States of America 98101,

206-971-8000, 1-855-515-1144

Submission Info

Topics:

Metabolite Regulation of Epigenetics and Gene Expression

Metabolites and Signaling

Metabolites in Cancer

Metabolites in Organismal Physiology and Aging

Metabolites and the Microbiota

Abstracts received before the abstract deadline will be considered for poster presentations and/or a limited number of oral presentations. If your abstract is accepted, it will be included in our online abstract booklet that will be distributed to all conference participants.

Any abstracts submitted after the deadline will be eligible for poster presentations only. Please also note that we can only allow one abstract per presenting author. Abstracts will not be published and authors also reserve the right to publish their work elsewhere.

All abstracts will be reviewed by the organizers to ensure that the topic of the submission is consistent with the scope of the topics covered at the symposium. A small number of abstracts will be selected for short talks by the organizing committee.

Once the abstracts is accepted, at least one of the authors must register for and present at the conference.

A condition of submission is that, if accepted, the poster and/or talk will be presented at the conference by one of the authors.

Successfully submitted abstracts will be acknowledged with an electronic receipt including an abstract reference number, which should be quoted in all correspondence.

For revisions or queries regarding abstracts already submitted please contact the Publishing Content Coordinator, Jafar Ali Meera Mohideen.

If you do not receive acknowledgement for your abstract submission or you wish to make any essential revisions to an abstract already submitted, please do not resubmit your abstract, as this may lead to duplication. Please contact the Conference Content Executive (Please do not email credit card information under any circumstances) with details of any revisions or queries. Please quote your reference number if you have one.

Elsevier Family Support Awards

Elsevier Family Support Awards

We are excited to announce that Elsevier has provided funds to help supplement the costs related to childcare responsibilities for early-career researchers attending our 2018 Cell Symposia. We understand that, in both academia and industry, the years following the completion of a doctoral degree are critical for exposure, recognition, and networking in order to secure or maintain a position. For many scientists, these years also coincide with starting a family, making it difficult to achieve a work-life balance and embrace one’s career objectives. Up to $500 per award will be granted to students, postdocs, and/or young investigators (within your first 5 years). Delegates with accepted abstracts are eligible for this award (awarded on a first come first serve basis).

Please contact: e.birnie@elsevier.com to receive an application form.

Abstract submission deadline 2018-08-29

Contact No.: +1 212 989 5800

Email: a.​cascio@​elsevier.​com

Contact No.: +1 212 989 5800

Email: a.​cascio@​elsevier.​com